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排序方式: 共有2838条查询结果,搜索用时 41 毫秒
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Tetsuji Terazawa Jin Matsuyama Masahiro Goto Ryohei Kawabata Shunji Endo Motohiro Imano Shoichiro Fujita Yusuke Akamaru Hirokazu Taniguchi Mitsutoshi Tatsumi Sang-Woong Lee Yoshitaka Kurisu Hisato Kawakami Yukinori Kurokawa Toshio Shimokawa Daisuke Sakai Takeshi Kato Kazumasa Fujitani Taroh Satoh 《The oncologist》2020,25(2):119-e208
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Hitoshi Nagai RMS Takamasa Oda MD PhD Fumiaki Nakao MD PhD Takeshi Ueyama MD PhD Yasuhiro Ikeda MD PhD 《Echocardiography (Mount Kisco, N.Y.)》2020,37(10):1698-1700
Transthoracic coronary Doppler echocardiography (TCDE) can be useful for the detection of chronic total occlusion (CTO) of the proximal left anterior descending coronary artery (LAD) noninvasively, by detecting retrograde flow through the distal LAD or its septal branch. This intriguing case report details the detection of abnormal blood flow in the right ventricular free wall by TCDE. This detection of abnormal flow may be useful to predict CTO of the LAD, even in the absence of retrograde flow in the LAD and its septal branch. 相似文献
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Kentaro Matsuo Kohei Taniguchi Hiroki Hamamoto Yosuke Inomata Kazumasa Komura Tomohito Tanaka Sang-Woong Lee Kazuhisa Uchiyama 《Cancer science》2021,112(8):2984-2992
Delta-like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and apoptosis. DLL3 is expressed throughout the presomitic mesoderm and is localized to the rostral somatic compartments; mutations in DLL3 induce skeletal abnormalities such as spondylocostal dysostosis. Recently, DLL3 has attracted interest as a novel molecular target due to its high expression in neuroendocrine carcinoma of the lung. Moreover, a DLL3-targeting Ab-drug conjugate, rovalpituzumab tesirine (ROVA-T), has been developed as a new treatment with proven antitumor activity. However, the development of ROVA-T was suspended because of shorter overall survival compared to topotecan, the second-line standard treatment. Thus, several studies on the mechanism and function of DLL3 in several malignancies are underway to find a new strategy for targeting DLL3. In this review, we discuss the roles of DLL3 in various malignancies and the future perspectives of DLL3-related research, especially as a therapeutic target. 相似文献
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Takashi Anayama Kentaro Hirohashi Ryohei Miyazaki Hironobu Okada Marino Yamamoto Kazumasa Orihashi 《The Journal of international medical research》2021,49(2)
ObjectiveTo determine the appropriate amount of indocyanine green for bronchial insufflation.MethodsWe enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green (0.0125 mg/mL) was insufflated into the subsegmental bronchi in the targeted pulmonary segmental bronchus. The volume of the targeted pulmonary segments was calculated using preoperative computed tomography. Fluorescence spread in the segmental alveoli was visualized using a dedicated near-infrared thoracoscope.ResultsThe targeted segment was uniformly visualized by indocyanine green fluorescence in 16/20 (80.0%) cases after insufflating indocyanine green. A receiver operating characteristic curve indicated that the area under the curve was 0.984; the optimal cut-off volume of diluted indocyanine green for insufflation was 8.91% of the calculated targeted pulmonary segment volume.ConclusionsThe setting for indocyanine green insufflation was optimized for near-infrared fluorescence image-guided anatomical segmentectomy. By injecting the correct amount of indocyanine green, fluorescence-guided anatomical segmentation may be performed more appropriately. 相似文献
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Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial 下载免费PDF全文
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Eosinophilic granuloma of the ramus similar to malignant neoplasm or osteomyelitis: Report of a case
Tsuyoshi Sato D.D.S. D.D.Sc. Yasuhiko Morita D.D.S. Ryutaro Oku D.D.S. Prof. Takenori Noikura D.D.S. D.M.Sc. Hiroshi Mukai D.D.S. D.M.Sc. Kazumasa Sugihara D.D.S. D.M.Sc. Prof. Sukehide Yamashita M.D. D.D.S. D.M.Sc. Motoo Kitano D.D.S. D.M.Sc. 《Oral Radiology》1990,6(2):63-68
An eosinophilic granuloma was discovered in the region of the ramus of the mandible. This case occured in a very rare location
limited only to the ramus, and showed similar features resembling osteomyelitis or malignant neoplasm at different stages
of the disease. The radiographic findings indicated a diagnosis of malignant neoplasm and the scintigraphic manifestations
showed that of osteomyelitis. The histopathological examinations showed different manifestations in accordance with the respective
stages of the disease. This case was finally diagnosed as eosinophilic granuloma showing rapid regression. 相似文献
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Hiroyuki Nakano Yoshihide Mori Takamitsu Mano Katsuhiro Minami Ken Matsumoto Yoshiya Ueyama Yoshiaki Yura 《Oral and maxillofacial surgery》2010,14(2):119-121